The NHS Louisa Jordan is set to close on Thursday, with the vaccination centre being moved to the Hydro next week.
Since July 2020, the hospital has played a critical role in the fight against Covid-19.
The hospital has carried out more than 32,000 healthcare appointments, training more than 6900 healthcare staff and students and vaccinating about 175,000 people.
Wednesday will be the last day of outpatient and diagnostic appointments, all training and blood donations.
Vaccinations will continue until April 3 at the current site before moving to the Hydro location within the Scottish Events Campus from April 6.
Once relocated to the SSE Hydro, the NHS Louisa Jordan vaccination centre will continue, in partnership with other NHS Boards, to run daily clinics for members of the public to receive their Covid-19 vaccination with the ability to administer up to 10,000 vaccinations per day.
Jill Young, chief executive of NHS Louisa Jordan, said: “Thanks to the continued efforts of the public, NHS Louisa Jordan was not needed to treat Covid inpatients. However, it has made a huge impact as part of NHS recovery and remobilisation of our health system.
“Without NHS Louisa Jordan, thousands of people would not have had outpatient and diagnostic appointments, important research and training would not have been carried out, and as one of the largest vaccinations centres in the UK we have clearly played a vitally important role to protect our NHS and save lives.
“NHS Louisa Jordan has been a true collaboration from inception to decommission. I want to thank everyone who has supported the establishment and running of NHS Louisa Jordan over the last year and vaccinations going forward.”
Equipment from NHS Louisa Jordan, such as CT scanners, will be repurposed and transferred for use in other NHS facilities, helping to ensure the facility brings further benefits to patients across Scotland.