More than £11m in funding has been awarded to two research groups at the University of Dundee.
Around £5.9m has been set aside to help establish a Centre for Dermatology and Genetic Medicine for research into the causes of skin diseases and developing new medicines for inherited skin disorders.
A £5.4m grant has also been given to the Centre for Gene Regulation and Expression (GRE), which studies the cell biology of gene expression and chromosome biology.
The funding has come from The Wellcome Trust, a global charitable foundation dedicated to achieving extraordinary improvements in human and animal health.
Professor Doreen Cantrell, head of the College of Life Sciences at Dundee, said: "These grants offer recognition of the outstanding basic and translational life sciences research that goes on in Dundee."
Professor Irwin McLean said the Wellcome grant could shorten the time it will take to bring new skin disease therapies into clinical use.
He said: "We are enormously grateful to The Wellcome Trust for awarding this strategic grant in recognition of the strong international reputation of the Dundee skin science groups in identifying the causes of skin diseases and developing new medicines for inherited skin disorders.
"This award, to establish the Centre for Dermatology and Genetic Medicine, will allow us to rapidly expand our capability to find the causes of the remaining unsolved skin conditions using cutting edge genome sequencing technology and to expand our dermatology drug discovery programme. Importantly, this large injection of funding will shorten the time to take our new therapies closer to clinical use."
The grant will fund eighteen new research posts, 15 of them full-time positions.