More than 15cm of snow is due to fall over parts of the country on Friday.
The Met Office has put an amber weather warning in place across parts of Highlands and Eliean Siar, Grampian, Strathclyde, Central, Tayside and Fife and south-west Scotland, Lothian and Borders for Friday.
Yellow weather warnings are in effect in areas which are expected to miss the worst of the weather.
STV weatherman Sean Batty warned of more road closures and disruption on Friday. He also said storms are due to hit the country next week with a risk of flooding.
He said: “The colder weather is on the way out, but before we get the rise in temperatures there's some more snow to contend with.
“A mix of rain and hill snow can be expected in western areas. Further east significant falls of snow can be expected with 5-10cm falling widely over the likes of Stirlingshire, Perthshire, Angus, south and west Aberdeenshire, Borders, Dumfries & Galloway and parts of Fife.
“Heavier falls will occur over higher levels with over 15cm in places. This will add to the snow already lying and could amount up to a snow depth of 40-50cm for some.
“Again the snow will be accompanied by a strong wind which will lead to blizzards and drifting of the snow. Already some parts of the east have deep drift and this is only going to get worse in Friday afternoon & evening's conditions.
“Again there is likely to be more road closures with the snow heavy, wet and driven on by a strong wind there is a risk of power loss as ice piles up on the lines.”
He said snow would be seen in other areas including the Edinburgh and Lothians area but said this would later turn to rain.
“The temperatures during the weekend will slowly begin to rise and a spell of heavy rain will cross the country on Saturday night increasing the thawing of lying snow,” he added.
“Next week deep low pressure systems will move in from the Atlantic bringing stormy conditions, especially to western areas, and also a risk of flooding.”
Weather map:Snow expected across the country
Traffic Scotland has warned motorists of the potential for snow and ice on all routes across the country.
The Multi-Agency Response Team (MART), based in the Traffic Scotland Control Centre in Glasgow, will monitor conditions and provide assistance across the transport network.
Transport Scotland has also organised a meeting with the police, the Met Office and operating companies on Thursday afternoon to receive an update on preparations.
Transport minister Keith Brown said: "According to the latest Met Office forecast, a combination of freezing temperatures, hard packed ice and fresh snow will mean a testing journey for some people tomorrow. I would urge the public to take on board police advice about driving to the conditions, planning ahead and taking notice of travel updates. Despite the high level of service and winter treatments provided, sudden weather changes can occur, and stopping distances increase tenfold when driving in snow and ice.
"Our multi-agency response team (Mart) will be operational for the duration of the difficult conditions. The Scottish Government's resilience team is also monitoring the situation as it develops to ensure a co-ordinated response.
"The public can stay up to date with live travel information and local radio reports and familiarise themselves with advice for driving in testing conditions. The Traffic Scotland website, internet radio bulletins and Variable Message Signs are being used to provide up to date information as the situation develops."
Assistant chief constable Allan Moffat, speaking on behalf of the Association of Chief Police Officers in Scotland, said: "There is now an Amber warning in place for large areas of Scotland which will be affected by snow and ice and where there may be disruption to travel. This means that people should be prepared for severe weather conditions and make appropriate arrangements.
“We would urge people to be aware of the threat of disruption and to check with radio and TV bulletins and online before making their journey. It is also important that the advice and warnings given to those wishing to travel in the areas affected are heeded as the conditions may be hazardous."
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