Four children are among eight people taken to hospital after a collision involving three vehicles.
The accident, involving a van, lorry and camper van, happened two miles west of Creetown in Dumfries and Galloway at around 3am on Friday.
Three adults and four children from the camper van are in Dumfries and Galloway Infirmary with various injuries.
The driver of the van was airlifted to the hospital with serious injuries. The lorry driver was not injured.
A Dumfries and Galloway police spokesman said: "We are appealing for any witnesses who may have seen the crash to get in touch.
"Road diversions to take traffic around the crash have been put in place and drivers are asked, if possible, to avoid the area until the road is reopened."
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