Flooding and landslides have cut off both main rail lines connecting Scotland and England.
The West Coast line has been closed by a landslip at Tebay in Cumbria as well as flooding at Oxenholme Lake District station.
Buses have replaced trains between Lancaster and Carlisle, adding about 60 minutes to journeys.
Night sleeper services have been cancelled and further disruption is expected after a freight train derailed on the West Highland Line near Corrour at about 7pm.
On the East Coast line, a landslip near Berwick-on-Tweed is causing serious disruption and adding two hours to journey times.
No trains are running between Durham and Berwick-on-Tweed and no replacement bus service is available.
Newcastle station was closed by flooding and a lightning strike that knocked out signalling. The station reopened just after 6.30pm.
CrossCountry trains have been cancelled between Darlington and Scotland.
Flooding near Haltwhistle, in Northumberland, has blocked the line between Hexham and Carlisle.
East Coast Trains and Virgin Trains say tickets for Thursday will be valid on Friday and have advised people to delay their journey if they can.
The National Rail Enquiries Twitter feed reported: "Flooding and landslips are causing heavy delays on routes between Northern England and Scotland, with very limited travel options".
Northumbria Police has received reports of local road floding on the A69 and A68 through Northumberland.
"Drivers are advised to take extra care when travelling, reduce their speed and exercise caution on the roads that are affected," a spokesman said.
FURTHER INFORMATION
East Coast Trains travel information
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