Two more patients suffering from a diarrhoea and vomiting bug have died at the Royal Alexandra Hospital in Paisley.
Six patients in total, who were thought to have the Norovirus, have now died at the hospital.
NHS Greater Glasgow and Clyde said that the deaths were caused by underlying medical conditions although diarrhoea and vomiting was a contributory factor in one of the deaths earlier in the week.
A spokeswoman said: "Our thoughts and sympathies are with the families."
One ward at the hospital reopened on Wednesday but seven wards remain closed to new admissions.
Twenty two patients are currently showing symptoms of the virus.
Outwith the wards affected the RAH continues to run as normal.
Patients who have outpatient appointments or have a planned hospital admission are being asked to attend these as usual.
Dr Teresa Inkster, NHS Greater Glasgow and Clyde consultant microbiologist, said: "We are seeing an increase in cases coming into the hospital from the community where we know there are more cases than usual of diarrhoea and vomiting.
"People can help limit the spread of the virus by ensuring good hand hygiene at all times and if they have concerns contacting their GP or NHS24 for advice.
"Novovrius is particularly prevalent in both the community and in healthcare settings. Typically it has a sudden onset and can spread quickly.
"Most people will recover from the virus within 24 or 48 hours. Unfortunately when people are very ill for other reasons, it can be more difficult for them to cope with diarrhoea and vomiting."
For more information on norovirus, visit the STV Health Centre, brought to you by NHS inform.
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