A group of American politicians will travel to the Scottish Parliament to hold a three-day conference.
It will be the first time the National Conference of State Legislatures has met outside the United States.
The announcement was made during Scotland Week, which celebrates ties between the countries.
The announcement follows an agreement at the weekend to bring a collection of Andy Warhol's prints and paintings to Holyrood for a free exhibition later this year.
The conference will take place over July 10-12 and bring together house speakers, senate presidents, majority and minority leaders from legislatures from the 50 states.
Holyrood's Presiding Officer Tricia Marwick said the conference will help showcase Scotland and Parliament to an international audience.
"The conference will provide a platform for politicians on both sides of the Atlantic to discuss a range of issues which affect the lives of both Scots and Americans alike," she said.
"I look forward to chairing the lively and thought-provoking debate the conference will no doubt provide."
Conference president Terie Norelli, Speaker of the New Hampshire House of Representatives, said: "Our conference is always an important time for us to gather as legislative leaders and reflect. To be able to do this in the inspiring landscape of Scotland and the dramatic building of Holyrood will be a fantastic opportunity.
"We are heartened by the Presiding Officer's warm welcome for our first conference outside the United States. There is much we can learn from each other's experiences and I know delegates will be particularly keen to learn more about Scotland from a business and cultural perspective."
Other speakers at the conference will include professor Tom Devine of the University of Edinburgh.
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