First Minister Alex Salmond will lead a trade delegation to London this week as the world's attention turns towards the capital for the start of the 2012 Olympics.
The mission aims to exploit the global interest in the Games by showcasing Scottish industries and promoting investment in the country, officials said.
A special facility on Pall Mall, dubbed Scotland House, will host more than 40 formal and informal events to help promote what the country has to offer to a global audience.
Mr Salmond will be joined by Finance Secretary John Swinney; Shona Robison, the Minister for the Commonwealth Games and Sport; External Affairs Secretary Fiona Hyslop and Rural Affairs Secretary Richard Lochhead, as part of the "extensive programme of engagement" over the coming weeks.
Mr Swinney said: "The Scottish Government and our enterprise agencies are working tirelessly to secure new jobs and investment to Scotland - the 2012 Olympics provide a good opportunity to showcase Scotland's strengths on an international stage.
"Thousands of key influences in the world of business, tourism and sport will be travelling to London for this event and we will be making sure they hear our clear message that Scotland is a great place to live, work and do business."
Details of the mission emerged after a week in which it which it was confirmed that Scotland has followed the UK economy into double-dip recession. Unemployment, however, fell for the fourth month in a row.
"Our trade mission will build on our ongoing work to strengthen recovery and stimulate growth," Mr Swinney added.
The mission is part of the Holyrood administration's plan to reach major UK and overseas companies that currently do not have operations in Scotland.
The First Minister will launch Scotland House and a programme of events towards the end of the week.
He will also represent Scotland at the Olympics' Opening Ceremony on Friday evening, while Mr Swinney will meet international businesses and diplomats at the Olympics Global Investment Conference on Thursday.