A Remploy factory in Lanarkshire is to shut with many others in Scotland under threat as part of a UK-wide round of Government cuts.
The announcement was made in Westminster on Tuesday and Wishaw is one of 28 Remploy factories, which provides employment opportunities for disabled people, in the UK that will be shut down.
The closure will affect 22 people including 20 disabled workers.
An MP has criticised the announcement saying Remploy workers have been "shafted" by the government.
Maria Miller, Minister for Disabled People, told MPs the £320m budget for disabled employment services could be spent more effectively.
She also announced a further consultation on the future of nine other Remploy factories, including Aberdeen, Edinburgh and Springburn in Glasgow, which have been the subject of bids.
East Kilbride MP Michael McCann took to Twitter after the announcement to say: "Remploy workers shafted by HMG."
And Motherwell and Wishaw MP Frank Roy said that workers in Wishaw have been "thrown on the scrapheap".
The Government announced in March that Remploy was planning to close 36 of its 54 factories, putting more than 1,700 jobs at risk.
The factories were established 66 years ago as part of the creation of the welfare state.
Disabled workers are employed in enterprises that vary from furniture and packaging manufacturing to recycling electrical appliances and operating CCTV systems and control rooms.
Union sources said the 27 factories will close between August and mid-December.
Workers at Remploy's 54 factories are due to stage two 24-hour strikes in the coming weeks in protest at an announcement by the Government earlier this year of closures.
The GMB union said the strikes would go ahead despite today's announcement.
Phil Davies, national officer of the GMB union, said: "GMB is very angry with the Government's confirmation today that it will close 27 Remploy factories in the first wave by December with the rest to follow shortly afterwards.
"To close these factories that employ disabled people in the present economic climate is a sentence to life of unemployment and poverty."
Kevin Hepworth, Unite's national officer, said: "Remploy workers will be taking strike action to defend their jobs as the axe is wielded by the Government.
"By taking strike action they are trying to avoid their certain destiny of being chucked on the economic scrapheap. They deserve the support of all trade unionists and the public in Britain."
Enterprise Minister Fergus Ewing said: "It is welcome news that full bids are being sought for the three Remploy factories in Aberdeen, Edinburgh and Springburn.
"The continuation of jobs for Remploy staff has been a priority for the Scottish Government and our partners since they were put under threat in March.
"Clearly this process is still ongoing and final details are not yet available but we will continue to work with DWP and the bidders and are hopeful of a positive future for these sites.
"The situation in Netherton is disappointing and I know this will be a difficult time for the employees there."
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